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. 2021 Feb 9;12:614483. doi: 10.3389/fphys.2021.614483

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Copyright © 2021 Fenner, Gatta, Sattler, Kuiper, Hesselkilde, Adler, Smerup, Schotten, Sørensen, Diness, Jespersen, Verheule, Van Hunnik and Buhl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NS8593 pharmacokinetics and its effect on the atrial fibrillation cycle length (AFCL). (A) Plasma concentration of NS8593 measured at time points T = –5, 0, 5, 10, and 30 min relative to the start of drug infusion. (B) Influence of NS8593 on right atrial tissue refractoriness in persistent AF (blue) and acutely induced AF (gray). The depicted data on acute AF (gray) are derived from unpublished data from Haugaard et al. The shown data points represent the AF cycle length (AFCL) measured at the start of drug infusion (T₀) and at the end of the 20-min observational period following the end of drug injection (T₃₀, persistent AF study), as well as immediately before cardioversion (acute AF study), respectively. Inf., infusion. Statistical significance is defined as p < 0.05 and is marked with an asterisk (^∗).