FIGURE 6.

Influence of NS8593 on conduction patterns accountable for AF maintenance: ectopy and re-entrant circuits with focus on inter-atrial heterogeneity. AF parameters between baseline (T_–5), 10 min (T₁₀), and 20 min (T₂₀) after the start of infusion in left atrium (LA) and right atrium (RA) (A) Waves/cycle. Significant increase in the number of waves/cycle in the RA, whereas no change can be observed for the LA. (B) Breakthrough waves. Significant increase in the number of breakthrough waves in the RA, whereas no change can be observed in the LA. (C) Presence of re-entrant circuits. As seen in Figure 3, re-entrant circuits were rarely observed events. There was no significant change in the percentage of time re-entrant circuits were present. (D) Average (∅) maximal rotation. Stability (maximal rotation) of observed re-entrant circuits was not significantly affected. Statistical significance is defined as p < 0.05 and is marked with an asterisk (^∗).