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. 2021 Feb 9;12:614483. doi: 10.3389/fphys.2021.614483

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Copyright © 2021 Fenner, Gatta, Sattler, Kuiper, Hesselkilde, Adler, Smerup, Schotten, Sørensen, Diness, Jespersen, Verheule, Van Hunnik and Buhl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of NS8593 on conduction properties. AF parameters between baseline (T_–5), 10 min (T₁₀), and 20 min (T₂₀) after the start of infusion in left atrium (LA) and right atrium (RA) (A) AFCL. Left atrial AFCL is shorter than right atrial AFCL at T₀. After NS8593 administration, both RA and LA AFCL increased equally, maintaining the RA-LA gradient. (B) CV_AF. Significant decrease in conduction velocity in AF (CV_AF) in the RA, whereas no change can be observed in the LA. (C) Anisotropy index. Significant increase in direction dependence (anisotropy) in the RA, whereas no change was observed in the LA. (D) Electrical dissociation. Significant increase in electrical dissociation in the RA, whereas no change was observed in the LA. Statistical significance is defined as p < 0.05 and is marked with an asterisk (^∗).