Table 3.
Univariate and multivariate analysis for predictors of combined HIV persistent control and independent predictors of persistent virological and combined control respectively
| Univariate analysis | ||||
|---|---|---|---|---|
| Variable | Years to combined progression a | PYFU | Events (N)/total | p value |
| Age | ||||
| ≤38 | 4 (0.7 to 7.3) | 633 | 23/31 | 0.09 |
| >38 | 4 (1.6 to 6.4) | 400 | 25/28 | |
| Sex | ||||
| Male | 4 (0.7 to 7.3) | 576 | 30/35 | 0.78 |
| Female | 4 (0.2 to 7.8) | 457 | 18/24 | |
| Risk for HIV acquisition | ||||
| Parenteral | 5.5 (3.5 to 7.5) | 611 | 24/30 | 0.15 |
| MSM | 3 (0 to 6.1) | 213 | 15/16 | |
| HET | 3 (1.6 to 4.4) | 182 | 7/11 | |
| HCV | ||||
| Negative serology | 3.5 (1.6 to 5.4) | 332 | 22/26 | 0.1 |
| Positive serology | 5 (2.2 to 7.8) | 701 | 26/33 | |
| HCV cure | ||||
| Cured | 4 (0.9 to 7) | 450 | 16/18 | 0.16 |
| Not cured | 11 (0 to 24.8) | 251 | 10/15 | |
| Viral load blips 1st year | ||||
| No | 6 (1.4 to 10.6) | 824 | 33/44 | 0.003 |
| Yes | 2 (1 to 2.9) | 209 | 15/15 | |
| Multivariate analysis | ||||
|---|---|---|---|---|
| Independent predictors | Hazard Ratio (95% CI) | p value | ||
| Virological progression | ||||
| Sexual risk for HIV acquisition | 2.2 (1.1 to 4.2) | 0.020 | ||
| Viral load blips 1st year | 2.1 (1.1 to 4.0) | 0.026 | ||
| Combined progression | ||||
| Viral load blips 1st year | 2.5 (1.3 to 4.6) | 0.005 | ||
A univariate analysis using Kaplan–Meier estimates and log‐rank tests was performed. Potential determinants of clinical events in the multivariate analysis were analysed using Cox regression models. HCV, Hepatitis C Virus evaluated at baseline; HET, Heterosexual; MSM, Men who have sex with men; PYFU, Person‐years of follow‐up.
a
Estimated median (Interquartile Range).