Table 2.
Comparison of WBC and lymphocyte subsets between day 0 and 7
| Parameter* | Day 0 |
Day 7 |
p value | ||
|---|---|---|---|---|---|
| median | IQR | median | IQR | ||
| WBC | 5,880 | (4,702–8,417) | 7,130 | (5,230–9,755) | 0.001** |
| PMN, % | 63.5 | (53.0–73.3) | 56.4 | (48.3–67.5) | 0.004** |
| Lymphocyte, % | 25.1 | (17.3–31.3) | 30.0 | (22.3–37.3) | 0.019** |
| Total lymphocyte | 1,416 | (1,035–1,936) | 1,808 | (1,498–2,391) | <0.0001** |
| T cells | 863 | (551–1,237) | 1,255 | (932–1,548) | <0.0001** |
| CD4+ T cells | 598 | (347–821) | 787 | (576–920) | <0.0001** |
| CD8+ T cells | 256 | (141–357) | 394 | (248–478) | <0.0001** |
| CD4+/CD8+ (ratio) | 2.7 | (1.6–3.4) | 2.2 | (1.5–3.2) | 0.132 |
| Treg cells# | 49 | (6–108) | 55 | (0–186) | 0.286 |
| FOXP3+ MFI# | 6.5 | (5.1–14.5) | 4.2 | (3.6–14.1) | 0.859 |
| CD27+ lymphocytes | 275 | (126–507) | 344 | (202–611) | 0.003** |
| CD38+ lymphocytes | 166.5 | (112.5–225.5) | 273.4 | (196.6–370) | <0.0001** |
| CD3+HLA DR+ | 44.3 | (0–86) | 82.9 | (9.6–216) | 0.003** |
| CD19+ B cells | 146 | (87–300) | 184 | (100–304) | 0.189 |
| CD20+ B cells | 136 | (85–280) | 171 | (102–284) | 0.188 |
| NK cells | 201 | (149–302) | 265 | (183–380) | 0.014** |
IQR, interquartile range; WBC, white blood cell; PMN, polymorphonuclear; Treg, regulatory T lymphocyte (CD3+CD25+FOXP3+); MFI, median fluorescent intensity; NK, natural killer.
*
All parameters are counts (cells per cubic millimeter) other than specified.
**
Statistically significant.
#
FOXP3 marker was checked for 31 samples on the 1st day and 11 samples on the 7th day.