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. 2021 Jan 15:1–14. doi: 10.1159/000513686

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Copyright © 2021 by S. Karger AG, Basel

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Fig. 1 — Structure of SARS-CoV-2 and its genome organization [40, 92, 93, 94]. N protein is a major facilitator of viral replication within host cells, where it interacts with viral RNA during replication to form the virion after attachment to Nsp3 of the RTCs. RNA also interacts with M proteins via N. RTCs facilitate viral RNA replication. SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; RTC, replication-transcription complex; Nsp, nonstructural protein; S, spike, E, envelope; M, matrix; EM, electron microscopy.