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Domain organization of Mpro. a The 3 domains are shown as domain I (residues 8–101), domain II (residues 102–184), and domain III (residues 201–303). b Dimers. Catalytic residues (C145 and H41) are circled. In SARS-CoV-2, T285 is replaced by A285 (black balls) and Ile286 is replaced by leucine. SARS-CoV-2, severe acute respiratory syndrome coronavirus-2
