Table 1.

Effects of LGZ or PCM on the pharmacokinetic parameters of SN in blood and extracellular fluid of rat brain tissue.

PK parameter	SN levels
	SN	SN + LGZ	SN + LGZ	SN + PCM	SN + PCM
	(50 mg·kg−1)	(50 mg·kg−1 + 50 mg·kg−1)	(25 mg·kg−1 + 25 mg·kg−1)	(50 mg·kg−1 + 50 mg·kg−1)	(25 mg·kg−1 + 25 mg·kg−1)
BLOOD
AUC0−t (h·μg·mL−1)	14.80 ± 6.13	15.19 ± 4.45	6.25 ± 1.02**	7.72 ± 3.02*	3.72 ± 0.58**
AUC0−∞ (h·μg·mL−1)	15.01 ± 6.20	15.42 ± 4.50	6.36 ± 1.04**	7.84 ± 3.07*	3.84 ± 0.6**
MRT (h)	1.12 ± 0.28	1.05 ± 0.16	0.87 ± 0.08	1.13 ± 0.14	0.98 ± 0.24
t1/2 (h)	0.94 ± 0.26	0.97 ± 0.30	0.80 ± 0.17	0.87 ± 0.21	0.96 ± 0.21
Vz (L·kg−1)	5.30 ± 2.45	4.64 ± 1.31	4.56 ± 0.94	7.60 ± 2.95	9.01 ± 1.49**
CLz (L·h−1·kg−1)	3.75 ± 1.31	3.46 ± 0.90	4.01 ± 0.59	6.35 ± 2.61*	6.65 ± 1.11**
Cmax (μg·mL−1)	10.07 ± 2.75	10.38 ± 1.60	5.26 ± 1.09**	6.11 ± 1.91*	3.32 ± 0.46**
BRAIN
AUC0−t (h·μg·mL−1)	0.91 ± 0.17##	0.77 ± 0.25##	0.32 ± 0.04**##	0.89 ± 0.29##	0.41 ± 0.13**##
AUC0−∞ (h·μg·mL−1)	0.99 ± 0.15##	0.89 ± 0.26##	0.39 ± 0.05**##	0.93 ± 0.32##	0.48 ± 0.13**##
MRT (h)	1.75 ± 0.37##	1.42 ± 0.39	1.05 ± 0.05**##	1.60 ± 0.08##	1.47 ± 0.39#
t1/2 (h)	1.14 ± 0.27	1.22 ± 0.19	1.18 ± 0.34	1.09 ± 0.34	1.35 ± 0.34
Tmax (h)	0.33 ± 0.18	0.33 ± 0.18	0.39 ± 0.17	0.50 ± 0.00	0.37 ± 0.18
Cmax (μg·mL−1)	0.43 ± 0.13##	0.45 ± 0.14##	0.24 ± 0.05**##	0.47 ± 0.12##	0.23 ± 0.09*##
BRAIN-TO-BLOOD AUC RATIOS
Kp	0.07 ± 0.03	0.06 ± 0.02	0.06 ± 0.01	0.12 ± 0.01**	0.11 ± 0.03**

N = 6 rats, data presented as Mean ± SD.

^*P < 0.05,

^**P < 0.01, Parameters of SN in SN+LGZ or SN+PCM groups were compared with those in the SN group, respectively;

^#P < 0.05,

^##P < 0.01, parameters of extracellular fluid of rat brain tissue were compared with that of blood tissue, respectively.