Table 2.

Effects of SN on the pharmacokinetic parameters of LGZ or PCM in blood and extracellular fluid of rat brain tissue.

PK parameter	LGZ levels			PCM levels
	LGZ	LGZ + SN	LGZ + SN	PCM	PCM + SN	PCM + SN
	(50 mg·kg−1)	(50 mg·kg−1 + 50 mg·kg−1)	(25 mg·kg−1 + 25 mg·kg−1)	(50 mg·kg−1)	(50 mg·kg−1 + 50 mg·kg−1)	(25 mg·kg−1 + 25 mg·kg−1)
BLOOD
AUC0−t (h·μg·mL−1)	76.73 ± 14.27	94.94 ± 18.75	26.87 ± 5.83**	18.06 ± 5.94	23.78 ± 9.08	9.96 ± 3.7*
AUC0−∞ (h·μg·mL−1)	78.02 ± 14.06	96.24 ± 19.02	27.9 ± 5.89**	18.2 ± 6.01	24.08 ± 9.18	10.08 ± 3.71*
MRT (h)	1.04 ± 0.11	1.21 ± 0.22	0.78 ± 0.14**	0.70 ± 0.17	0.92 ± 0.16*	0.87 ± 0.37
t1/2 (h)	1.36 ± 0.30	1.40 ± 0.27	1.29 ± 0.43	0.73 ± 0.22	0.85 ± 0.31	0.77 ± 0.32
Vz (L·kg−1)	1.48 ± 0.58	1.07 ± 0.27	1.71 ± 0.56	2.91 ± 0.28	2.84 ± 1.38	3.05 ± 1.70
CLz (L·h−1·kg−1)	0.66 ± 0.13	0.54 ± 0.10	0.93 ± 0.20*	3.03 ± 1.07	2.37 ± 0.98	2.81 ± 1.09
Cmax (μg·mL−1)	50.04 ± 8.83	51.99 ± 7.08	23.63 ± 5.37**	16.53 ± 4.1	17.12 ± 4.08	8.66 ± 3.82**
BRAIN
AUC0−t (h·μg·mL−1)	53.81 ± 17.72#	57.81 ± 22.38#	16.38 ± 4.25**##	9.3 ± 2.22##	10.81 ± 3.90##	5.01 ± 2.14#
AUC0−∞ (h·μg·mL−1)	54.57 ± 18.11#	58.42 ± 22.6#	16.82 ± 4.18**##	9.43 ± 2.27##	10.95 ± 3.96##	5.08 ± 2.17#
MRT (h)	1.03 ± 0.12	1.18 ± 0.17	0.85 ± 0.06*	0.99 ± 0.14##	1.09 ± 0.14	1.09 ± 0.35
t1/2 (h)	1.06 ± 0.13	1.19 ± 0.43	1.19 ± 0.36	0.50 ± 0.11	0.59 ± 0.07	0.58 ± 0.19
Tmax (h)	0.28 ± 0.17	0.17 ± 0.00	0.17 ± 0.00	0.56 ± 0.14	0.50 ± 0.00	0.50 ± 0.00
Cmax (μg·mL−1)	38.14 ± 9.21#	34.73 ± 12.37#	15.1 ± 2.45**##	7.24 ± 1.31##	7.29 ± 1.57##	3.85 ± 1.00**#
BRAIN-TO-BLOOD AUC RATIOS
Kp	0.69 ± 0.16	0.60 ± 0.17	0.62 ± 0.11	0.54 ± 0.14	0.47 ± 0.1	0.54 ± 0.28

N = 6 rats, data presented as Mean ± SD.

^*P < 0.05,

^**P < 0.01, Parameters of LGZ/PCM in SN+LGZ or SN+PCM groups were compared with those in the LGZ/PCM group, respectively;

^#P < 0.05,

^##P < 0.01, parameters of extracellular fluid of rat brain tissue were compared with those of blood tissue, respectively.