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A schematic illustration of mesocorticolimbic network and reward system. (A) Standard stimuli (e.g., food) motivate tonic dopamine response in the outer shell of the nucleus accumbens; repeated stimuli induce habitation with the response shifting to its core. (B) In substantia nigra, dopamine autoreceptors offer feedback to regulate synaptic dopamine concentrations. (C) The OFC and ACC make adjustments for optimizing future choices and balance the system.
