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. 2021 Feb 9;10:584024. doi: 10.3389/fonc.2020.584024

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Copyright © 2021 Jakobsen, Traynor, Stæhr, Duijf, Nielsen, Terp, Pedersen, Guldberg, Ditzel and Gjerstorff

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of VCX gene promotor methylation levels and mRNA expression. Spearman correlation between average promotor methylation levels, shown as ß-values and mRNA expression of all VCX family genes in healthy and cancerous breast tissue and melanoma. A significant correlation was observed for all VCX family genes in both breast cancer and melanoma, but not in healthy breast tissue. Blue indicates primary tumor specimens and red indicates metastatic tumor specimens. The p-values were calculated using the (unpaired) Mann-Whitney U test.