Table 6.
Logistic univariate and multivariate regression analyses on the association between the corticosteroid treatment and the clinical features.
| Univariable OR (95% CI) | P-value | Multivariable OR (95% CI) | P-value | |
|---|---|---|---|---|
| Age≥60 years | 3.53 (1.39–9.02) | 0.008 | 4.94 (1.49–16.41) | 0.009 |
| Sex | 0.70 (0.28–1.75) | 0.449 | ||
| Laboratory findings | ||||
| White blood cell count (X109/L) | 1.15 (1.02-1.30) | 0.022 | 1.19 (1.03-1.37) | 0.019 |
| 4–10 | ref | |||
| <4 | 0.38 (0.10–1.39) | 0.142 | ||
| >10 | 2.59 (0.78–8.58) | 0.120 | ||
| Lymphocyte count (×109/L) | 0.58 (0.31–1.08) | 0.085 | ||
| 1.5–4.0 | ref | ref | ||
| <1.5 | 2.61 (1.61–4.22) | <0.001 | 1.79 (0.63–5.06) | 0.271 |
| >4.0# | / | / | ||
| Neutrophil count (×109/L) | 1.16 (1.02–1.31) | 0.023 | 1.21 (1.04–1.40) | 0.016 |
| 2–7 | ref | ref | ||
| <2 | 1.00 (0.25–4.00) | 1.000 | ||
| >7 | 4.43 (1.95–10.06) | <0.001 | 2.32 (0.82–6.61) | 0.115 |
| NLR | 1.13 (1.03–1.23) | 0.008 | 1.16 (1.03–1.29) | 0.011 |
| 0.78–3.53 | ref | ref | ||
| <0.78# | / | / | ||
| >3.53 | 3.22 (1.90–5.47) | <0.001 | 3.51 (1.30–9.49) | 0.013 |
| Monocyte count (×109/L) | 1.58 (0.34–7.46) | 0.561 | ||
| 0.12–1.00 | ref | |||
| <0.12# | / | / | ||
| >1.00# | / | / | ||
| Platelet count (×109/L) | 0.99 (0.99–1.00) | 0.029 | 0.99 (0.99–1.00) | 0.059 |
| 99–303 | ref | |||
| <99 | 2.75 (0.88–8.64) | 0.083 | ||
| >303 | 0.80 (0.22–2.98) | 0.739 | ||
| APTT(s) | 0.97 (0.94–1.01) | 0.136 | ||
| 21–37 | ref | |||
| <21 | 1.00 (0.63–15.99) | 1.000 | ||
| >37 | 1.77 (0.90–3.49) | 0.100 | ||
| Fibrinogen (g/L) | 0.93 (0.70–1.23) | 0.596 | ||
| 2–4 | ref | |||
| <2 | 3.00 (1.09–8.25) | 0.033 | 1.40 (0.37–5.34) | 0.626 |
| >4 | 1.55 (0.72–3.30) | 0.261 | ||
| D-dimer (μg/mL) | 1.05 (0.96–1.15) | 0.293 | ||
| 0-0.55 | ref | ref | ||
| >0.55 | 3.14 (1.72–5.74) | <0.001 | 2.67 (1.00–7.15) | 0.050 |
| Procalcitonin (ng/mL) | 1.22 (0.74–2.03) | 0.440 | ||
| 0-0.50 | ref | ref | ||
| >0.50 | 4.25 (1.43–12.63) | 0.009 | 2.27 (0.62–8.40) | 0.218 |
| CRP(mg/L) | 1.00 (1.00–1.01) | 0.193 | ||
| 0–10 | ref | ref | ||
| >10 | 2.61 (1.61–4.22) | <0.001 | 1.63 (0.59–4.44) | 0.344 |
| ESR (mm/1h) | 1.00 (0.99–1.01) | 0.679 | ||
| 0-30 | ref | ref | ||
| >30 | 2.05 (1.23–3.41) | 0.006 | 1.29 (0.48–3.53) | 0.614 |
| Creatine kinase (U/L) | 1.00 (1.00–1.00) | 0.902 | ||
| 25–200 | ref | ref | ||
| <25 | 2.00 (0.18–22.06) | 0.571 | ||
| >200 | 2.75 (1.22–6.18) | 0.014 | 1.30 (0.40–4.28) | 0.663 |
| Lactate dehydrogenase (U/L) | 1.00 (1.00–1.00) | 0.546 | ||
| 44–112 | ref | ref | ||
| <44# | / | / | ||
| >112 | 2.06 (1.15–3.68) | 0.015 | 1.01 (0.38–2.72) | 0.981 |
| Creatinine (μmol/L) | 1.00 (1.00–1.01) | 0.588 | ||
| 91–230 | ref | ref | ||
| <91# | / | / | ||
| >230 | 3.12 (1.41–6.93) | 0.005 | 2.10 (0.71–6.20) | 0.180 |
| BUN (mmol/L) | 1.00 (0.99–1.01) | 0.627 | ||
| 2.5–7.1 | ref | ref | ||
| <2.5 | 2.00 (0.18–22.06) | 0.571 | ||
| >7.1 | 2.40 (1.31–4.38) | 0.004 | 1.38 (0.56–3.42) | 0.485 |
| AST (U/L) | 1.00 (1.00–1.00) | 0.620 | ||
| 0–40 | ref | ref | ||
| >40 | 2.22 (1.36–3.63) | 0.002 | 0.89 (0.32–2.46) | 0.817 |
| ALT (U/L) | 1.00 (1.00–1.00) | 0.620 | ||
| 0–50 | ref | ref | ||
| >50 | 3.13 (1.75–5.60) | <0.001 | 2.90 (1.06–7.97) | 0.039 |
| Total bilirubin (μmol/L) | 1.01 (0.97–1.05) | 0.544 | ||
| 0–21 | ref | ref | ||
| >21 | 3.29 (1.81–5.98) | <0.001 | 2.36 (0.85–6.55) | 0.098 |
| SOFA | 1.17 (1.05–1.31) | 0.005 | 1.21 (1.07–1.38) | 0.004 |
| 1 | ref | ref | ||
| 2–5 | 1.21 (0.60–2.46) | 0.591 | 1.11 (0.31–3.95) | 0.872 |
| 6–10 | 2.83 (1.12–7.19) | 0.028 | 1.82 (0.38–8.64) | 0.453 |
| >10 | 5.67 (2.34–13.50) | <0.001 | 6.31 (1.34–29.73) | 0.020 |
OR, odds ratio; CI, confidence interval. Multivariable logistic regression for age were adjusted for sex and comorbidities. Multivariable logistic regression for laboratory findings were adjusted for age, sex and comorbidities. NLR, neutrophil-to-lymphocyte ratio; APTT, activated partial thromboplastin time; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; BUN, blood urea nitrogen; AST, aspartate transaminase; ALT, alanine aminotransferase; SOFA, sequential organ failure assessment. The bold P-values indicate P < 0.05.
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Too few cases.