Table 2.
Changes from baseline, before the second pallidothalamic tractotomy (PTT), and at 1 year after bilateral PTT.
| Baseline | Before second side | p (Wilcoxon) | 1 year after second | p (Wilcoxon) | |
|---|---|---|---|---|---|
| (n = 10) | (n = 8) | side (n = 10) | |||
| Total Unified Parkinson's Disease Rating Scale (UPDRS), on-medication (/199) | 60 ± 23 | 54 ± 16 | 0.89 | ||
| Total UPDRS, off-medication (/199) | 65 ± 25 | 57 ± 14 | 0.48 | 29 ± 11 | 0.007* |
| UPDRS I (/16) | 3.7 ± 2.4 | 3.4 ± 1.6 | 0.82 | 2.2 ± 1.7 | 0.13 |
| UPDRS II (/52) | 15 ± 6 | 15 ± 4 | 0.72 | 10 ± 3 | 0.07 |
| Speech (item 5) (/4) | 0.9 ± 0.9 | 1.6 ± 0.8 | 0.053* | 2.1 ± 0.7 | 0.02* |
| UPDRS III on-medication (/108) | 35 ± 18 | 30 ± 14 | 0.83 | ||
| UPDRS III off-medication (/108) | 41 ± 20 | 33 ± 12 | 0.4 | 16 ± 9 | 0.005* |
| First operated side, UPDRS III, on-medication (/36)a | 17 ± 6 | 6.6 ± 6.1 | 0.025* | ||
| First operated side, UPDRS III, off-medication (/36)a | 20 ± 6 | 6.7 ± 6.2 | 0.017* | 3.6 ± 3.5 | 0.005* |
| Second operated side, UPDRS III, on-medication (/36)a (n = 8) | 9.3 ± 9.1 | 16 ± 8 | 0.025* | ||
| Second operated side, UPDRS III, off-medication (/36)a (n = 8) | 12 ± 11 | 18 ± 7 | 0.036* | 4.9 ± 2.7 | 0.09 |
| Tremor, both sides on-medication (/24)b | 11 ± 6 | 6.7 ± 4.8 | 0.53 | ||
| Tremor, both sides off-medication(/24)b | 13 ± 6 | 7.5 ± 3.9 | 0.08 | 0.9 ± 2.1 | 0.006* |
| Tremor, first operated side on-medication (/12)c | 6.0 ± 3.2 | 1.7 ± 2.6 | 0.065 | ||
| Tremor, first operated side off-medication (/12)c | 7.5 ± 2.7 | 1.4 ± 1.9 | 0.014* | 0.4 ± 0.9 | 0.008* |
| Tremor, second operated side on-medication (/12)c | 3.5 ± 3.3 | 5.0 ± 3.2 | 0.44 | ||
| Tremor, second operated side off-medication (/12)c | 4.6 ± 3.8 | 6.1 ± 3.0 | 0.57 | 0.5 ± 1.2 | 0.03* |
| Rigidity, both sides on-medication (/16)d | 5.3 ± 3.2 | 3.9 ± 3.0 | 0.83 | ||
| Rigidity, both sides off-medication (/16)c | 6.4 ± 3.8 | 5.4 ± 2.4 | 0.44 | 1.8 ± 1.8 | 0.006* |
| Distal hypobradykinesia both sides on-medication (/32)e | 12.6 ± 6.9 | 7.9 ± 6.5 | 0.44 | ||
| Distal hypobradykinesia both sides off-medication (/32)e | 14.0 ± 7.7 | 11.9 ± 5.1 | 0.78 | 5.8 ± 4.5 | 0.01* |
| Axial items UDPRS III on-medication (/32)f | 7.5 ± 5.1 | 6.0 ± 4.3 | 1.00 | ||
| Axial items UDPRS III off-medication (/32)f | 8.0 ± 5.2 | 8.6 ± 4.3 | 0.62 | 7.4 ± 4.0 | 0.88 |
| Speech on-medication (/4) (item 18) | 1.0 ± 0.8 | 0.7 ± 0.8 | 0.93 | ||
| Speech off-medication (/4) (item 18) | 1.0 ± 0.8 | 1.1 ± 0.8 | 0.32 | 1.5 ± 0.7 | 0.06 |
| Gait (item 29) on-medication (/4) | 0.8 ± 0.7 | 1.0 ± 0.9 | 0.4 | ||
| Gait (item 29) off-medication (/4) | 1.0 ± 0.6 | 1.0 ± 0.7 | 1.00 | 0.7 ± 0.6 | 0.67 |
| Postural instability (item 30) on-medication (/4) | 1.0 ± 1.0 | 0.8 ± 0.5 | 0.94 | ||
| Postural instability (item 30) off-medication (/4) | 1.0 ± 1.0 | 1.1 ± 0.6 | 0.94 | 0.9 ± 0.7 | 0.83 |
For UPDRS scores, higher values indicate stronger impairments. P-values were calculated with baseline using non-parametric Wilcoxon matched-pairs signed-ranks test. In the last column, p-values are given for comparisons between postoperative off-medication and baseline on-medication (except UPDRS I and II items).
n, number of interventions included in the analysis;
p-values which reached statistical significance after correction.
UPDRS III items 20.2, 20.4, 21.1, 22.2, 22.4, 23.1, 24.1, 25.1, 26.1 or 20.3, 20.5, 21.2, 22.3, 22.5, 23.2, 24.2, 25.2, and 26.2 on operated side (i.e., partial UPDRS III).
UPDRS III items 20 and 21.
UPDRS III items 20.2, 20.4, 21.1 or 20.3, 20.5, and 21.2.
UPDRS III items 22.2, 22.3., 22.4, and 22.5.
UPDRS III items 23, 24, 25, and 26.
UPDRS III items 18, 19, 22, 27, 28, 29, 30, and 31.