TABLE 1.

Pathogenic variants detected in three pregnant patients with Alport syndrome.

Patient	Pathogenic gene	Transcript ID	DNA variant	Amino acid changes	Classification of variants#
No. 1	COL4A5	NM_000495.4	c.1834G > A	p.(Gly612Arg)	Likely pathogenic
No. 2	COL4A5	NM_000495.4	c.888_889del	p.(Gly298*)	Pathogenic
No. 3	COL4A5	NM_000495.4	c.1933C > T	p.(Gln645*)	Pathogenic

^#The interpretation and classification of variants was based on ACMG guideline (Richards et al., 2015). *Termination of protein translation.