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. 2021 Feb 16;34(7):108759. doi: 10.1016/j.celrep.2021.108759

Figure 5.

Figure 5

Uncoupling of replication forks efficiency at origins of replication near TSSs

(A) Average metagene profile for the denotated strand of strand-specific Ok-seq from Chen et al. (2019) TSSs ±50 kb of transcribed genes >100 kb in BJ-hTERT cells.

(B) As for (A) but for TSSs ±10 kb, with orange and black arrows indicating the start positions of the Okazaki fragments on “+” or “−” strands.

(C) Average metagene profile for Ok-seq from Chen et al. (2019) TSSs ±10 kb of transcribed genes >100 kb or G-MiDS hotspot genes in BJ-hTERT without strand specificity.

(D) Average metagene profile for Ok-seq transcribed/not-transcribed strand from Petryk et al. (2016) TSSs ± 50 kb of transcribed genes >100 kb in HeLa cells on + or − strands.

(E) Average metagene profile of MCM7 (Sugimoto et al., 2018), RPA2 (Zhang et al., 2017), and ORC1 (Dellino et al., 2013) ChIP-seq in HeLa cells at TSSs of transcribed genes >100 kb.