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. 2021 Feb 9;12:601511. doi: 10.3389/fphar.2021.601511

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Copyright © 2021 Schyman, Xu, Desai and Wallqvist.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screenshot of typical results for gene sets activated by the liver toxicant, thioacetamide. Headings: Gene Set—name of gene set, injury module, or pathway; Filter—type of gene set (e.g., KEGG pathway) displayed when selected; Aggregate Fold Change z-Score—positive for an up-regulated gene set and negative for a down-regulated gene set; Aggregate Absolute Fold Change z-Score—gene-set activation, as calculated by summing the changes in the expression levels for all genes within the gene set; Aggregate p-Value—Fisher’s combined p-value for all genes in the gene set.