Figure 3.

The diverse immune characteristics and heterogeneity of genetic phenotypes of non-immune class, immune-activated subgroup, and immune-exhausted subgroup

(A) Division and characterization of three immunophenotypes. CYT, cytolytic activity score; TITR, tumor-infiltrating Tregs; MDSC, myeloid-derived suppressor cell; TLS, tertiary lymphoid structure; C-ECM, cancer-associated extracellular matrix. (B) Difference of tumor-infiltrating lymphocyte abundance. (C) Difference in the PD-L1 mRNA expression level. (D) Difference in gene copy number alterations, including amplification and deletion, among arm levels and focal levels. (E) Difference the tumor mutation burden. (F) Difference in tumor neoantigens. (G) Specific mutant genes in the immune-activated subgroup. (H) Specific mutant genes in the immune-exhausted subgroup. WT, wild-type; IM-Act, immune-activated subgroup; IM-Exh, immune-exhausted subgroup.