Table 1.
List of compounds screened with Dose-dependent inhibition analysis: All the compounds were treated with 0.3 x 10−9 M of MtuUng followed by addition of 30 x 10−9 M of the fluorescence -labelled oligomer. The reaction volume was taken to be 100 μl buffered by 50 mM Tris-Cl (pH 8), 1 mM Na2EDTA and 37.59 nM BSA (n = 3).
| S. No. | Inhibitor | Structure | Docking Score | IC50 in mM (mean ± SEM) |
|---|---|---|---|---|
| 1 | Uracil | ![]() |
−10.268 | 2.05 ± 0.3 |
| 2 | 4-Thio-Uracil | ![]() |
−4.806 | 3.57 ± 0.35 |
| 3 | 5- Iodo-Uracil | ![]() |
−9.103 | 4.92 ± 0.51 |
| 4 | 5-Chloro-Uracil | ![]() |
−8.805 | 8.71 ± 0.70 |
| 5 | 5-Fluoro-Uracil | ![]() |
−8.963 | 50.18 ± 3.85 |
| 6 | 5-Nitro-Uracil | ![]() |
−5.054 | 10.77 ± 0.32 |
| 7 | 5-Amino-Uracil | ![]() |
−9.636 | 7.18 ± 0.97 |
| 8 | 5-Bromo-Uracil | ![]() |
−8.733 | 13.59 ± 0.73 |
| 9 | Barbituric acid | ![]() |
−12.03 | 7.29 ± 0.32 |








