Figure 1.

Large soft drusen are defined on SD-OCT B-scans as sub-RPE deposits with a horizontal diameter greater than 125 µm and indistinct borders, while hard drusen are defined as sub-RPE deposits with less than 63 µm in size and distinct borders at the level of Bruch's membrane. A near-infrared reflectance image (A) shows the level of the B-scan in panel C. A color fundus photograph (B) shows many typical soft drusen. An example of a soft druse with the maximum horizontal extent of 758 µm and of a small hard druse with a horizontal extension of 57 µm is indicated in panel (C).