Figure 2.
Lipid accumulation in the RPE of Pnpla2-cKO mice. Electron microscopy micrographs showing the RPE structure of 3-month-old (A) and 13-month-old (B) cKO mice and control animals. Scale bar: 2 µm. The representative images were selected among examinations of micrographs from eight eyes of cKO mice (PNPLA2f/f/Cre+), from seven eyes of PNPLA2f/f control mice at 1.75 to 3.75 months old, and from three eyes of cKO mice and three eyes of control mice at 12.5 to 13 months old. LD, lipid droplets; BI, basal infoldings.