Weighted infective endocarditis hospitalizations with and without substance use disorder diagnoses, Premier Healthcare Database, 2012–2017. Includes opioids, cocaine, amphetamines, hallucinogens, or other/unspecified drugs (see Supplementary Materials). Abbreviations: IE-SUD, infective endocarditis hospitalization with substance use disorder diagnoses; IE-Non-SUD, infective endocarditis hospitalization without substance use disorder diagnoses.