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. Author manuscript; available in PMC: 2021 Apr 23.
Published in final edited form as: Clin Infect Dis. 2020 Oct 23;71(7):e37–e44. doi: 10.1093/cid/ciaa008

Table 2.

Rates of Hospitalizations for Selected Infections, Thyroid Disorders, and Leukemia With Substance Use Disorder Diagnoses, Premier Healthcare Database, 2012–2017

Year
2012 2013 2014 2015 2016 2017
Infective endocarditis
18–44 years Weighted N 1803 2048 2328 2579 3002 4089
Rate per 100 000 persons 1.6 1.8 2.1 2.3 2.6 3.6
45–64 years Weighted N 614 755 696 830 783 972
Rate per 100 000 persons 0.7 0.9 0.8 1.0 0.9 1.2
65+ years Weighted N 60 39 43 62 45 38
Rate per 100 000 persons 0.1 0.1 0.1 0.1 0.1 0.1
Osteomyelitis
18–44 years Weighted N 1332 1590 2076 2141 2229 2884
Rate per 100 000 persons 1.2 1.4 1.8 1.9 2.0 2.5
45–64 years Weighted N 1639 1691 2104 1983 2361 2750
Rate per 100 000 persons 2.0 2.1 2.5 2.4 2.8 3.3
65+ years Weighted N 252 269 330 359 396 308
Rate per 100 000 persons 0.6 0.6 0.7 0.8 0.8 0.6
Central nervous system abscess
18–44 years Weighted N 525 537 605 703 784 1036
Rate per 100 000 persons 0.5 0.5 0.5 0.6 0.7 0.9
45–64 years Weighted N 604 566 682 717 834 1047
Rate per 100 000 persons 0.7 0.7 0.8 0.9 1.0 1.3
65+ years Weighted N 72 84 84 62 96 97
Rate per 100 000 persons 0.2 0.2 0.2 0.1 0.2 0.2
Skin and soft tissue infection
18–44 years Weighted N 32 620 36 859 38 270 41 093 43 061 47 111
Rate per 100 000 persons 29.3 33.0 34.1 36.4 37.9 41.4
45–64 years Weighted N 22 276 24 072 26 405 26 708 28 011 29 079
Rate per 100 000 persons 27.2 29.4 32.0 32.1 33.5 34.9
65+ years Weighted N 2466 3183 3691 4101 4211 4743
Rate per 100 000 persons 5.9 7.4 8.3 8.9 8.9 9.6
Thyroid disease
18–44 years Weighted N 292 331 371 389 361 343
Rate per 100 000 persons 0.3 0.3 0.3 0.3 0.3 0.3
45–64 years Weighted N 245 402 355 368 305 310
Rate per 100 000 persons 0.3 0.5 0.4 0.4 0.4 0.4
65+ years Weighted N 115 78 79 103 56 91
Rate per 100 000 persons 0.3 0.2 0.2 0.2 0.1 0.2
Leukemia
18–44 years Weighted N 153 167 179 167 243 192
Rate per 100 000 persons 0.1 0.1 0.2 0.1 0.2 0.2
45–64 years Weighted N 210 227 267 253 289 235
Rate per 100 000 persons 0.3 0.3 0.3 0.3 0.3 0.3
65+ years Weighted N 125 118 140 91 87 130
Rate per 100 000 persons 0.3 0.3 0.3 0.2 0.2 0.3

Includes opioids, cocaine, amphetamines, hallucinogens, or other/unspecified drugs (Supplementary Materials).