. Author manuscript; available in PMC: 2021 Feb 23.

Published in final edited form as: SLAS Discov. 2017 Jul 11;22(9):1093–1105. doi: 10.1177/2472555217717200

Table 1.

Results of Screen for Inhibitors of Tyrosyl-DNA Phosphodiesterase 1.

	Total Screened	Initial Positives	Confirmed Hits	Final Hit Rate (%)

Synthetic compounds	8258	30	9	0.1
Pure natural products	4043	43	10	0.25
Prefractionated extracts	71,642	113	59	0.1
Crude extracts	143,962	348	39	0.03
	Plants: 106,738	Plants: 149	Plants: 3	Plants: 0.003
	Algal: 2464	Algal: 34	Algal: 9	Algal: 0.36
	Fungal: 19,272	Fungal: 87	Fungal: 17	Fungal: 0.09
	Marine: 15,488	Marine: 78	Marine: 10	Marine: 0.06
Total	227,905	534	117	0.05