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. Author manuscript; available in PMC: 2021 Feb 23.
Published in final edited form as: Biochem J. 2017 Feb 20;474(5):781–795. doi: 10.1042/BCJ20160748

Figure 4. Cul coupled dynamics and flexibility.

Figure 4.

(A) Contraction motions observed in complete closed state Cul5 MD simulation are shown by aligning the most contracted Cul conformation (Frame 547 — used in Figure 5; orange) on the initial complete Cul5 model (beige). (B) Cul5 conformer is colored according to the Cul5 correlations with Nedd8-acceptor Cul5 residue K724. Color code is done based on the normalized correlation values in the range of [−1,1], where −1 reflects highest negative correlation and 1 shows the highest positive correlations in fluctuation dynamics during the MD simulation. (C) The Cul5 domains (including NTD dynamic domains determined from the network of correlated motions) are labeled.