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CDX2 and CD274 expression in normal intestinal epithelium and colon carcinoma. (a–c) Sequential immunostaining of CDX2 (brown) and CD274 (red). (a,b) Normal intestinal epithelium including CDX2-negative epithelial cells of the terminal ileum (a) and colon (b) showed no CD274 expression. (c) A case of poorly differentiated adenocarcinoma of the colon with diffuse CD274 expression on the cell membrane without nuclear CDX2.
