Table 1A.
Clinicopathological characteristics of 454 colorectal carcinomas with or without CD274 expression
|
CD274 expression |
||||
|---|---|---|---|---|
|
Total no. 454 (100%) [100%] |
Positive 54 (12%) [100%] |
Negative 400 (88%) [100%] |
P-value | |
| Sex | 0.24a | |||
| Male | 202 (100%) [46%] |
20 (10%) [38%] |
182 (90%) [47%] |
|
| Female | 235 (100%) [54%] |
32 (14%) [62%] |
203 (86%) [53%] |
|
| Age, years (mean ± s.d.) | 68.1 ± 13.3 | 72.6 ± 13.1 | 67.4 ± 13.2 | 0.0080b |
| Tumor size, cm (mean ± s.d.) | 5.6 ± 2.6 | 6.1 ± 2.4 | 5.5 ± 2.6 | 0.19b |
| Tumor location | < 0.001a | |||
| Cecum and ascending colon | 191 (100%) [46%] |
33 (17%) [66%] |
158 (83%) [44%] |
|
| Transverse colon | 60 (100%) [15%] |
10 (17%) [20%] |
50 (83%) [14%] |
|
| Descending and sigmoid colon | 126 (100%) [31%] |
6 (5%) [12%] |
120 (95%) [33%] |
|
| Rectum | 36 (100%) [9%] |
1 (3%) [2%] |
35 (97%) [10%] |
|
| Tumor differentiation | < 0.001a | |||
| Well to moderate | 388 (100%) [85%] |
26(7%) [48%] |
362 (93%) [91%] |
|
| Poor | 66 (100%) [15%] |
28 (42%) [52%] |
38 (58%) [10%] |
|
| Mucinous histology | 0.058a | |||
| 0–49% | 418 (100%) [92%] |
46 (11%) [85%] |
372 (89%) [93%] |
|
| 50%– | 36 (100%) [8%] |
8 (22%) [15%] |
28 (78%) [7%] |
|
| Solid/medullary histology | < 0.001a | |||
| 0–49% | 417 (100%) [92%] |
34 (8%) [63%] |
383 (92%) [96%] |
|
| 50%– | 37 (100%) [8%] |
20 (54%) [37%] |
17 (46%) [4%] |
|
a
P-values were calculated by the χ2 test for CD274 expression.
b
T-test was used to compare the means of age and tumor size. The Bonferroni-corrected P-value for significance was P = 0.0041 (0.05/12).