Table 3.
Characterization of 16 CD274-positive colorectal carcinomas
| Age | Sex | Location | Size (cm) | Tumor differentiation | Mucinous histology | Solid/medullary histology | CD274 (%) Localization | CDX2 | ALCAM | ALDH1A1 | SALL4 | MLH1 | PMS2 | MSH2 | MSH6 | BRAF | KRAS | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 66 | F | HF | 8 | Poor | − | + | 100 | Membrane | − | + | − | − | − | − | + | − | MUT | WT |
| 62 | F | Colon NOS | — | Poor | − | − | 100 | Membrane | − | + | − | − | − | − | + | + | MUT | WT |
| 78 | M | T | 7 | Poor | − | + | 100 | Membrane | − | + | − | − | − | − | + | + | MUT | WT |
| 65 | F | S | 5 | Poor | − | + | 100 | Membrane | − | − | − | − | − | − | + | + | MUT | WT |
| 85 | M | Colon NOS | 6 | Well | − | − | 100 | Cytoplasm | + | + | − | − | − | − | + | + | MUT | WT |
| 86 | F | C | 4 | Well | + | − | 100 | Cytoplasm | + | − | + | − | − | − | + | + | MUT | WT |
| 77 | F | A | 6 | Poor | − | + | 80 | Cytoplasm | + | − | − | − | − | − | + | + | MUT | WT |
| 70 | F | A | 10 | Poor | − | + | 80 | Cytoplasm | + | + | + | − | − | − | + | + | MUT | WT |
| 81 | M | A | 8 | Moderate | − | − | 80 | Cytoplasm | + | + | + | − | − | − | + | + | MUT | WT |
| 80 | F | C | 9 | Moderate | − | − | 40 | Membrane | + | − | − | − | + | + | + | + | WT | WT |
| 65 | M | C | 6.5 | Well | − | − | 40 | Cytoplasm | + | − | − | − | − | − | + | + | MUT | WT |
| 61 | F | C | 4 | Well | − | − | 30 | Cytoplasm | + | − | − | − | − | − | + | + | MUT | WT |
| 66 | F | C | 3.5 | Well | − | − | 20 | Membrane | + | − | + | − | + | + | + | + | WT | Codon12 GGT>GAT |
| 71 | F | C | 5 | Well | − | − | 20 | Cytoplasm | + | + | + | − | − | − | + | + | MUT | WT |
| 82 | F | C | 7 | Moderate | − | − | 10 | Cytoplasm | + | − | + | − | − | − | + | + | MUT | WT |
| 77 | F | A | 4 | Moderate | − | − | 10 | Cytoplasm | + | − | + | − | − | − | + | + | MUT | WT |
Abbreviations: A, ascending colon; C, cecum; HF, hepatic flexure; T, transverse colon. WT, wild type. MUT, c.1799T > A (BRAF V600E) mutant.
No mutation was found in NRAS, PIK3CA, and GNAS.