Fig. 7: Manufacturing stream-based grouping of the bioactivity for individual petroleum substances.

Using the ToxPi score as an overall measure of bioactivity for each UVCB, striking differences are observed across UVCB categories (top). This phenomenon differs by cell type, with iCell hepatocytes showing two clear groups of bioactivity (middle), and iCell cardiomyocytes showing a gradation across the categories (bottom). Each dot represents a UVCB sample total ToxPi score derived from all phenotypes (top) or cell-specific phenotypes. Box is the inter-quartile range, vertical line is the median, and whiskers extend in most instances to the min-max range of values, and otherwise to the corresponding quartile plus 1.5X the interquartile range. See Figure S4¹ for the same data for other cell types.