FIGURE 2.

Effect of Lrap on alcohol consumption in genetically modified rats. Alcohol consumption by male rats (n = 9–12 rats/genotype) from the three genotypes (Lrap^+/+, Lrap^+/−, and Lrap^−/−) was determined using the two‐bottle choice paradigm with 10% ethanol solution. Circles represent values for individual rats. Each point is labeled with a number to facilitate access to raw data if needed. For alcohol consumption and alcohol preference, means ±1 standard error from the linear mixed model on log transformed values were transformed back to the original scale and reported in the graphic. For all four outcomes, post hoc pairwise comparisons were made between all three groups and only comparisons with a p value less than 0.05 are reported. (A) Alcohol consumption in grams per kilogram of body weight. (B) Alcohol preference measured as the volume of alcohol solution divided by the total volume of fluids consumed. (C) Average daily fluid consumption in milliliters. No significant (p < 0.05) differences among genotypes were found. (D) Body weight in grams. There were no significant differences in body weight (p < 0.05) among genotypes