TABLE 1.
Prioritization of transcripts within the alcohol consumption module for genetic manipulation
| Gene symbol | Genomic position | Correlation with alcohol consumption [correlation coefficient (p value)] | Association with alcohol consumption QTL on chromosome 12 [log base 2 difference (p value)] | Correlation with module eigengene [correlation coefficient (p value)] | Correlation‐based intramodular connectivity (rank within module) | Connectivity‐based intramodular connectivity (rank within module) | Number of connected nodes a in module (|correlation coefficient| > 0.3) | Percent of all edges in module that remain after adjustment for transcript |
|---|---|---|---|---|---|---|---|---|
| Lrap | chr12: 39.01 Mb | −0.55 (0.011) | −0.32 (0.0079) | 0.90 (4.1e‐08) | 10.66 (1) | 2.99 (1) | 16 | 41% |
| Ift81 | chr12: 39.42 Mb | −0.43 (0.051) | −0.17 (0.0015) | 0.88 (2.0e‐07) | 10.33 (2) | 2.66 (2) | 15 | 49% |
| Coq5 | chr12: 47.08 Mb | −0.50 (0.021) | −0.10 (0.0057) | 0.83 (2.6e‐06) | 9.94 (4) | 2.24 (3) | 15 | 65% |
| Txnip | chr2: 198.68 Mb | 0.61 (0.003) | 0.20 (0.0087) | −0.77 (4.6e‐05) | 9.09 (8) | 2.20 (4) | 13 | 74% |
| P2rx4 | chr12: 39.31 Mb | −0.63 (0.002) | −0.17 (0.0022) | 0.83 (3.6e‐06) | 9.86 (5) | 2.15 (5) | 16 | 62% |
| Tmem116 | chr12: 40.56 Mb | 0.34 (0.133) | 0.34 (0.0001) | −0.81 (7.5e‐06) | 9.95 (3) | 2.00 (6) | 16 | 49% |
| Maats1 | chr11: 64.98 Mb | −0.56 (0.008) | −0.05 (0.0772) | 0.65 (1.3e‐03) | 7.57 (14) | 1.95 (7) | 9 | 95% |
| GENE_27603 | chr6:42.79 Mb | −0.50 (0.021) | −0.12 (0.0298) | 0.70 (4.5e‐04) | 8.18 (11) | 1.74 (8) | 13 | 83% |
| Oas1f (formerly Oas1b) | chr12: 41.26 Mb | 0.34 (0.136) | 0.61 (0.0006) | −0.79 (2.2e‐05) | 9.61 (6) | 1.69 (9) | 16 | 53% |
| GENE_18197 | chr2:257.76 Mb | −0.40 (0.075) | −0.12 (0.0196) | 0.77 (3.9e‐05) | 9.25 (7) | 1.65 (10) | 15 | 68% |
| Parp3 | chr8: 115.17 Mb | −0.28 (0.221) | −0.05 (0.0159) | 0.67 (8.0e‐04) | 8.40 (10) | 1.47 (11) | 15 | 76% |
| GENE_03396 | chr1:259.43 Mb | 0.27 (0.240) | 0.22 (0.0032) | −0.65 (1.4e‐03) | 7.97 (12) | 1.44 (12) | 12 | 72% |
| Slc8b1 (formerly Slc24a6) | chr12: 41.57 Mb | 0.16 (0.496) | 0.11 (0.0004) | −0.62 (2.5e‐03) | 7.60 (13) | 1.42 (13) | 12 | 86% |
| Prkar1b | chr12: 17.61 Mb | 0.30 (0.192) | 0.07 (0.0721) | −0.68 (7.6e‐04) | 8.44 (9) | 1.41 (14) | 15 | 72% |
| GENE_04887.ISO_01 | chr10:21.98 Mb | 0.25 (0.266) | 0.08 (0.0113) | −0.49 (2.3e‐02) | 6.46 (16) | 1.28 (15) | 9 | 87% |
| Pcdhb5 | chr18: 30.40 Mb | −0.10 (0.668) | −0.06 (0.0497) | 0.54 (1.2e‐02) | 6.92 (15) | 1.25 (16) | 10 | 82% |
| Anxa11 | chr16: 3.87 Mb | 0.25 (0.271) | 0.02 (0.3611) | −0.50 (2.0e‐02) | 6.29 (17) | 1.05 (17) | 12 | 92% |
Note: Gene symbols that begin with 'GENE' are unannotated transcripts that were identified in the original transcriptome reconstruction. All correlation coefficients are based on a parametric Pearson correlation. None of the p values have been adjusted for multiple testing.
a
Nodes refer to transcripts in the module.