Table 1.
Echocardiographic characteristics and levels of miRNA according to severity of sMR
| Total study population (n = 66) | No/mild sMR (n = 22) | Severe sMR (n = 44) | P‐Value (No/mild sMR vs severe sMR) | |
|---|---|---|---|---|
| Echocardiographic characteristics | ||||
| Left ventricular end‐diastolic diameter, mm | 61 ± 10 | 58 ± 10 | 63 ± 10 | .041 |
| Left ventricular end‐diastolic volume, mL | 210 ± 82 | 190 ± 74 | 220 ± 84 | .160 |
| Left ventricular function | .447 | |||
| Moderately reduced (LVEF 30%‐40%), n (%) | 9 (14) | 4 (18) | 5 (11) | |
| Severely reduced (LVEF < 30%), n (%) | 57 (86) | 18 (82) | 39 (89) | |
| Left atrial volume, mL | 86 ± 35 | 66 ± 24 | 96 ± 35 | .001 |
| Right ventricular end‐diastolic diameter, mm | 39 ± 7 | 38 ± 8 | 39 ± 7 | .530 |
| Right atrial diameter, mm | 63 ± 10 | 59 ± 9 | 65 ± 10 | .023 |
| MR vena contracta width, mm | 9.6 ± 5.6 | 3.2 ± 2.9 | 12.8 ± 3.4 | <.001 |
| MR jet area, cm2 | 10.9 ± 7.4 | 3.2 ± 2.8 | 14.8 ± 5.9 | <.001 |
| Systolic pulmonary artery pressure, mm Hg | 51 ± 14 | 46 ± 11 | 53 ± 15 | .160 |
| miRNA | ||||
| miR‐21 | 0.19 ± 0.27 | 0.30 ± 0.28 | 0.13 ± 0.25 | .014 |
| miR‐29a | 0.15 ± 0.21 | 0.23 ± 0.2 | 0.11 ± 0.21 | .021 |
| miR‐122 | −0.02 ± 0.37 | 0.1 ± 0.4 | −0.07 ± 0.34 | .077 |
| miR‐132 | 0.02 ± 0.26 | 0.12 ± 0.24 | −0.03 ± 0.26 | .029 |
| miR‐133a | −0.19 ± 0.36 | −0.05 ± 0.41 | −0.25 ± 0.32 | .034 |
| miR‐let7i | 0.14 ± 0.24 | 0.23 ± 0.24 | 0.09 ± 0.22 | .020 |
Bold values indicate statistical significance. miRNAs were log‐transformed prior to analysis. MR indicates mitral regurgitation.