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. 2021 Jan 7;16(2):324–333. doi: 10.1021/acschembio.0c00841

Figure 2.

Figure 2

FTO Inhibitors are selective and competitive. (A) Synthesis of FTO inhibitors by Suzuki coupling. (B) Sigmoidal dose–response curves for FTO-02. Inhibition against FTO is shown in blue, and inhibition of ALKBH5 is shown in red. (C) Sigmoidal dose–response curves for FTO-04. Inhibition against FTO is shown in blue, and inhibition of ALKBH5 is shown in red. (D) Sigmoidal dose–response curves for FTO-12. Inhibition against FTO is shown in blue, and inhibition of ALKBH5 is shown in red. (E) Double reciprocal plot for FTO-02. FTO-02 inhibits FTO by a competitive mechanism. (F) Double reciprocal plot for FTO-04. FTO-04 inhibits FTO by a competitive mechanism.