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. 2021 Jan 7;16(2):324–333. doi: 10.1021/acschembio.0c00841

Figure 4.

Figure 4

FTO-04 inhibits GSC neurospheres formation in multiple patient-derived stem cell lines without impairing hNSC neurosphere growth. (A) Bright field images of neurospheres after 2 days of treatment with the FTO-04 inhibitor (20 μM) to normal human neural stem cells (hNSC) and glioblastoma cell lines (TS576, GBM-GSC-23 and GBM-6). (B) Size of neurospheres as quantified by ImageJ. Box and whisker plots show 10–90th percentile. N > 50 neurospheres per group. **p < 0.01, ****p < 0.0001, by Student’s t test.