Fig. 7.

circAGAP1 promoted clear cell renal cell carcinoma progression by targeting miR-15a-5p. a Nude mouse models were established via subcutaneous injection of A498 cells. After 4 weeks, the mice were assigned into three groups and intratumorally injected with siRNA NC, circAGAP1 siRNA alone or circAGAP1 siRNA combined with miRNA-15a-5p inhibitors. b, c Effects of si-circAGAP1 alone or in combination with miRNA-15a-5p inhibitors on tumor volume and tumor weight. d H&E staining displays the morphological landscapes of the inoculated tumors, and an IHC assay was performed to analyze the levels of E2F3, Ki-67, PCNA, cleaved caspase 3, Bax and Bcl-2 in the si-circAGAP1, si-circAGAP1+ miR15a-5p inhibitor and control groups