Table 1.

Differentially expressed (up and downregulated) miRNA in senescent versus old MSCs/osteoblasts.

Differentially Expressed - Up Regulated
	Wagner et al (180)	Kundratos et al (181)	Yoo et al (118)	Meng et al (182)	Chen et al (183)	Li et al (184)	Okada et al (77)	Hackl et al (120)	Pandey et al (92)
	Senescent	Senescent	Senescent	Senescent	Senescent	Senescent	Old	Old	Old
	MSCs	MSCs	MSCs	MSCs	Osteoblasts	Osteoblasts	MSCs	MSCs	MSCs
miR-132-3p				O	O
miR-136-5p				O	O
miR-140			O**				O
miR-224				O**		O
miR-27a-3p				O	O
miR-27b				O**		O
miR-30d			O	O**
miR-335		O**				O			O
miR-34a				O**				O
miR-369-5p	O			O
Differentially Expressed - Down Regulated
	Wagner et al (180)	Kundratos et al (181)	Yoo et al (118)	Meng et al (182)	Chen et al (183)	Li et al (184)	Okada et al (77)	Hackl et al (120)	Pandey et al (92)
	Senescent	Senescent	Senescent	Senescent	Senescent	Senescent	Old	Old	Old
	MSCs	MSCs	MSCs	MSCs	Osteoblasts	Osteoblasts	MSCs	MSCs	MSCs
let-7a				O**				O
miR-130b-5p		O		O
miR-15b-3p		O		O				O***
miR-16				O**				O
miR-17				O				O
miR-188-3p		O							O
miR-199b-5p			O	O
miR-19b				O**		O		O
miR-20a-5p				O	O			O***
miR-218-5p		O		O
miR-222-5p				O	O
miR-224-5p		O			O
miR-23b				O**				O
miR-29b			O				O
miR-335*					O				O
miR-337-3p		O							O
miR-424					O			O	O
miR-483-3p				O			O
miR-7-5p		O		O
miR-935		O						O

^*Denotes the less predominant arm of the miRNA hairpin.

^**Denotes 3p or 5p arm was specified in the original literature but not reflected in this table.

^***Denotes miRNA arm not specified in the original literature.