Figure 2.

Neutralization of Victoria and B.1.351 viruses by convalescent plasma

Plasma was collected in the UK before June 2020, during the first wave of SARS-CoV-2, in the early convalescent phase 4–9 weeks following admission to hospital.

(A) FRNT assays comparing neutralization of Victoria (orange) and B.1.351 (green) (n = 34).

(B) Neutralization assays of Victoria and B.1.351 with plasma obtained from patients suffering B.1.1.7 infection at the indicated times following infection.

(C and D) Comparison of FRNT₅₀ titers between B.1.351 and Victoria strains for convalescent and B.1.1.7 plasma, respectively. The Wilcoxon matched-pairs signed rank sum test was used for the analysis and two-tailed p values were calculated; geometric mean values are indicated above each column. The data underpinning the Victoria neutralization curves have been previously reported (Supasa et al., 2021). Individual FRNT₅₀ values are shown in Table S1.