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. 2021 Feb 23;184(8):2229–2238.e13. doi: 10.1016/j.cell.2021.02.044

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Figure S5 — Safety characterization of S-IV-P5-Vero-P2 virion in hamsters and K18-hACE transgenic mice, related to Figure 3

(A and B) The weight change (A) and disease (B) of hamsters (n = 5) that were intranasally infected with 5,000 TCID₅₀ of S-IV-P5-Vero-P2 virion. A high-titer stock of S-IV-P5-Vero-P2 virion used for this experiment was prepared by amplifying the virion on Vero-ORF3-E cells.

(C) Mouse weight loss after I.N. infection. Mice were infected with 2,500 TCID₅₀ of S-IV-P5-Vero-P2 virion (n = 4) or PBS mock (n = 4) via the I.N. route. The mean ± standard deviations are indicated.

(D) Mouse survival after I.N. infection.

(E) Mouse weight loss after I.C. infection. Mouse were inoculated with 500 TCID50 of S-IV-P5-Vero-P2 virion (n = 4) via the I.C. route. The mean ± standard deviations are indicated.

(F) Mouse survival after I.C. infection. A high titer stock of S-IV-P5-Vero-P2 virion used for this experiment was prepared by amplifying the virion on Vero-ORF3-E cells.