TABLE 2.
Univariate and multivariate analyses of risk factors associated with ESRD in patients with IgANa
| Factor | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| rs7083345-TT/CT | 1.75 (1.03, 2.99) | 3.90 × 10−2 | 1.90 (1.06, 3.39) | 3.00 × 10−2 |
| Age (yrs) | 1.01 (0.98, 1.03) | 5.85 × 10−1 | 0.99 (0.96, 1.03) | 7.03 × 10−1 |
| Sex (female) | 0.67 (0.40, 1.12) | 1.26 × 10−1 | 1.03 (0.57, 1.86) | 9.10 × 10−1 |
| Serum creatinine (μmol/liter) | 1.02 (1.01, 1.02) | <1.00 × 10−3 | ||
| eGFR (ml/min/1.73 m2) | 0.97 (0.96, 0.98) | <1.00 × 10−3 | 0.96 (0.95, 0.97) | <1.00 × 10−3 |
| Gd-IgA1 (U/ml) | 1.02 (1.00, 1.03) | 4.90 × 10−2 | 1.01 (0.99, 1.03) | 2.33 × 10−1 |
| Serum IgA (g/liter) | 0.93 (0.75, 1.15) | 4.99 × 10−1 | ||
| Time-averaged proteinuria (g/g) | 2.03 (1.67, 2.48) | <1.00 × 10−3 | 2.52 (1.89, 3.35) | <1.00 × 10−3 |
| Urine protein excretion (g/24 h) | 1.20 (1.09, 1.31) | <1.00 × 10−3 | ||
| Serum C3 (g/liter) | 0.43 (0.11, 1.70) | 2.29 × 10−1 | ||
| CKD stage | ||||
| 2/3 | 2.95 (1.51, 5.76) | 2.00 × 10−3 | ||
| 4/5 | 24.58 (9.77, 61.80) | <1.00 × 10−3 | ||
a
P values which are <0.05 are highlighted by boldface type. HR, hazard ratio.