TABLE 3.
Intra-network connectivity predicting depression levels in PD patients (N = 96).
| Predictors | Variable statistics |
Model statistics |
||||
| β (s.e.) | t | P | ΔR2 | F | p | |
| Step 1 (for all models) | ||||||
| Age | 0.09 (0.06) | 1.61 | 0.111 | 0.20 | 3.51 | 0.004 |
| Gender | 1.28 (1.14) | 1.12 | 0.26 | |||
| Educational years | 0.05 (0.17) | 0.27 | 0.788 | |||
| UPDRS-III | 0.21 (0.05) | 4.39 | <0.001 | |||
| MMSE | −0.04 (0.22) | −0.20 | 0.846 | |||
| Duration | −0.11 (0.28) | 0.42 | 0.679 | |||
| Step 2 | ||||||
| Model 1a | ||||||
| dDMN (Hippocampus_L) | 5.04 (1.43) | 3.53 | 0.001 | 0.23 | 6.91 | <0.001 |
| aSN (Frontal_Sup_Medial_R) | −2.57 (0.71) | −3.58 | 0.001 | |||
| SMN_15 (Cerebelum_Crus2_R) | 1.16 (0.57) | 2.02 | 0.047 | |||
| SMN_25 (Temporal_Sup_R) | – | – | – | |||
| Model 2 | ||||||
| dDMN (Hippocampus_L) | 5.58 (1.55) | 3.61 | 0.001 | 0.11 | 3.51 | 0.004 |
| Model 3 | ||||||
| aSN (Frontal_Sup_Medial_R) | −2.78 (0.78) | −3.56 | 0.001 | 0.10 | 5.22 | <0.001 |
| Model 4 | ||||||
| SMN_15 (Cerebelum_Crus2_R) | 1.58 (0.64) | 2.45 | 0.016 | 0.05 | 4.04 | 0.001 |
| Model 5 | ||||||
| SMN_25 (Temporal_Sup_R) | −2.48 (1.37) | −1.81 | 0.073 | 0.03 | 3.51 | 0.002 |
aPredictors included intra-connectivity of dDMN, aSN, SMN_15, and SMN_25. Using the stepwise method, connectivity of dDMN, aSN, and SMN_15 was significant and retained in the final model. SMN_15 could not survive the Bonferroni correction (p < 0.05/4). UPDRS-III, Unified Parkinson’s Disease Rating Scale-motor part III; MMSE, Mini-Mental State Examination; aSN (Frontal_Sup_Medial_R), anterior salience network (the right medial superior frontal gyrus); dDMN (Hippocampus_L), dorsal default mode network (the left hippocampus); SMN_15 (Cerebelum_Crus2_R), sensorimotor network_15 (the right Cerebelum_Crus2); SMN_25 (Temporal_Sup_R), sensorimotor network_25 (the right superior temporal gyrus).