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. 2021 Feb 9:M20-8148. doi: 10.7326/M20-8148

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This article is made available via the PMC Open Access Subset for unrestricted re-use for research, analyses, and text and data mining through PubMed Central. Acknowledgement of the original source shall include a notice similar to the following: "© 2020 American College of Physicians. Some rights reserved. This work permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited." These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 1. Mortality for remdesivir 10-d course vs. control (placebo or standard care). The black diamonds reflect pooled results from randomized controlled trials (listed above) that enrolled patients in the corresponding respiratory support subgroups. ACTT-1 = Adaptive COVID-19 Treatment Trial; ECMO = extracorporeal membrane oxygenation; RR = risk ratio; SIMPLE-2 = Study to Evaluate the Safety and Antiviral Activity of Remdesivir [GS-5734] in Participants With Moderate Coronavirus Disease [COVID-19] Compared to Standard of Care Treatment. Top. Overall. Bottom. Results by initial respiratory status. — control (placebo or standard care). The black diamonds reflect pooled results from randomized controlled trials (listed above) that enrolled patients in the corresponding respiratory support subgroups. ACTT-1 = Adaptive COVID-19 Treatment Trial; ECMO = extracorporeal membrane oxygenation; RR = risk ratio; SIMPLE-2 = Study to Evaluate the Safety and Antiviral Activity of Remdesivir [GS-5734] in Participants With Moderate Coronavirus Disease [COVID-19] Compared to Standard of Care Treatment. Top. Overall. Bottom. Results by initial respiratory status.