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. 2020 Mar 11;63(7):3701–3712. doi: 10.1021/acs.jmedchem.0c00012

Figure 4.

Figure 4

PXR, CYP3A4, and MDR1 expression in the liver of mice treated with garcinoic acid (1). Mice were treated with increasing doses of GA from 5 to 25 mg administered as a single bolus, and PXR mRNA (A) and protein expression (B, left panel) were measured in liver samples 24 h post-treatment. CYP3A4 (CYP3A11 in mice) and MDR1 protein expression were also investigated (B, middle and right panels); *p < 0.05; **p < 0.01. Liver histology was examined by hematoxylin and eosin (H&E) staining and IHC for PXR antigen (C).