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. Author manuscript; available in PMC: 2021 Feb 23.
Published in final edited form as: Sci Transl Med. 2020 Nov 25;12(571):eaba6334. doi: 10.1126/scitranslmed.aba6334

Fig. 3. Nonparametric and pathway analysis of CSF proteomic abnormalities caused by Vps35 depletion.

Fig. 3.

(A) Listed proteins are those detected only in the controls or in the Vps35 cKO mice, with microtubule-associated protein tau (MAPT) indicated in red. (B) Tau protein structural features are shown in the linear diagram. Peptide region identified by MS/MS is indicated with an arrow. (C) Scatterplot shows the P value distribution of over 800 proteins identified by pathway analysis as “regulator” proteins. (D) Listed proteins are the top six regulators, with lowest P values.