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. 2021 Feb 22;12(2):e00313. doi: 10.14309/ctg.0000000000000313

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© 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — Effect of biopsy supernatants (from patients with IBS-D with pain scores >5) in tissue from Na_V1.9 −/− compared with wild type mice. Bar charts illustrating (a) the reduced colonic afferent response to supernatant, (b) the comparable magnitude of evoked mechanosensitivity in wild type and Na_V1.9 −/− tissue before supernatant application, and (c) the lower change mechanosensitivity after supernatant application in tissue from Na_V1.9 −/− compared with wild type mice.