TABLE 1.

The expression and function of gasdermin family members in human.

Human GSDM	Expression pattern	Biological function	Activating enzyme	Disease	References
GSDMA	Gastrointestinal tract, skin, esophagus, stomach and mammary gland	Programmed cell death	Not known	Alopecia and Infammatory disorders	Saeki et al., 2000, 2007; Zhou et al., 2012; Soderman et al., 2015
GSDMB	Gastrointestinal tract, lung, lymphocytes, liver, colon, esophagus and cancer cells	Pyroptosis	Caspase-1, -3, -4, -6, -7 and granzyme A	Asthma, type I diabetes, ankylosing spondylitis, inflammatory disorders and cancer	Das et al., 2016; Chao et al., 2017; Chen Q. et al., 2019; Zhou et al., 2020
GSDMC	Gastrointestinal tract, trachea, spleen, esophagus, stomach and cancer cells	Pyroptosis	Caspase-8	Cancer	Kusumaningrum et al., 2018; Hou et al., 2020
GSDMD	Skin, esophagus, stomach, immune cells and cancer cells	Pyroptosis, inflammation, and host defense	Caspase-1, -4, -5, -8, -11, cathepsin G and neutrophil elastase	Infammatory disorders and cancer	Katoh and Katoh, 2004b; Sarhan et al., 2018; Burgener et al., 2019; Liu et al., 2020
GSDME	Brain, heart, kidney, placenta and cancer cells	Pyroptosis and antitumor immunity	Caspase-3 and granzyme B	Deafness and cancer	Van Laer et al., 1998; Rogers et al., 2017; Zhang et al., 2020
PJVK (DFNB59)	Auditory system	Not known	Not known	Deafness	Mujtaba et al., 2012; Liu et al., 2013