Figure 3.

15d-PGJ₂ ameliorated pathological symptoms for resolution of intestinal inflammation. (A) Mice were administrated with drinking water containing 2.5% DSS for 7 days, followed by normal drinking water for 4 days. 15d-PGJ₂ (2 mg/kg) or vehicle was intraperitoneally injected to mice every day during resolution phase of inflammation. (B) The change of body weight was monitored and (C) DAI was scored. (D) On day 7 (inflammation phase) and day 11 (resolution phase), the colon length was determined, compared with no DSS group. All data represent mean ± S.D. (n=3). ^* p < 0.05, ^** p < 0.01, and ^*** p < 0.001.