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. 2021 Feb 2;12:615803. doi: 10.3389/fimmu.2021.615803

Figure 7.

Figure 7

A proposed mechanism underlying the pro-resolving effects of 15d-PGJ2 on resolution of intestinal inflammation. 15d-PGJ2, is endogenously generated from arachidonic acid induced by COX-2 and subsequent HPGDS during resolution of intestinal inflammation. 15d-PGJ2 promotes intestinal inflammation through regulating macrophage polarization.