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. 2021 Feb 5;8:620044. doi: 10.3389/fmed.2021.620044

Table 2.

Subgroup analyses.

Pooled estimate Test of heterogeneity
N RR with 95% CI p-Value τ2 I2 p-Value
Demographic
Male 6 1.38 (1.25–1.51) <0.001 0.001 9.57 0.35
≥65 years 7 2.54(1.62–3.97) <0.001 0.24 89.33 <0.001
Comorbidity
Diabetes 11 1.19 (1.07–1.32) 0.001 0.012 54.15 0.016
Hypertension 9 1.07 (0.92–1.25) 0.351 0.029 60.58 0.009
CKD 7 1.57 (1.29–1.91) <0.001 0.036 69.18 0.003
CPOD 5 1.34 (1.18–1.52) <0.001 0.004 16.12 0.312
Stroke 2 1.80 (0.89–3.64) 0.100 0 0 0.37
Others
Smoking 6 1.13 (0.91–1.40) 0.242 0.027 46.57 0.09

N, number of study; RR, risk ratio; CI, confidence Interval; CKD, chronic kidney disease; CPOD, chronic obstructive pulmonary disease. Bold value indicates subgroup and significant p-value.