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. 2021 Feb 9;11:620159. doi: 10.3389/fphar.2020.620159

FIGURE 2.

FIGURE 2

ST improved endothelial function in SHRs (n = 8). (A) The chemical structure of ST. (B) Effect of ST treatment on blood pressure during eight weeks. * p < 0.05, SHR group compared with WKY group at SBP; △ p < 0.05, SHR + ST group compared with SHR group at SBP; ∇ p < 0.05, SHR group compared with WKY group and SHR + ST group compared with SHR group at DBP. (C) Detection of tension results of isolated thoracic aortic rings in above three groups. ∇ p < 0.05, SHR group compared with WKY group and SHR + ST group compared with SHR group; △ p > 0.05, among above three groups in every concentration of SNP. (D) Histopathological changes of aorta were observed by light microscopy after HE staining (200×) and Masson staining (200×). (E) Western blot analysis of the expression of eNOS and phospho-eNOS (p-eNOS) in WKY, SHR and SHR + ST groups. The data were presented in fold of control. (F) ELISA analysis of the level of NO in above three groups. (G) ELISA analysis of the level of ET-1 in above three groups. All data were shown as mean ± standard deviation (SD) (error bars) from eight independent biological repeats experiments, each of which included three technical repeats. * p < 0.05; ** p < 0.01.