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. 2021 Feb 3;12:583453. doi: 10.3389/fphys.2021.583453

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Copyright © 2021 Repetti, Majumder, De Oliveira, Meth, Yangchen, Sharma, Srivastava and Rohatgi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amiloride sensitive Isc is stimulated by an ERK dependent mechanism as demonstrated in a single experiment (A) and the composite data (B). MpkCCD cells were exposed either to static, FSS, or FSS with 10 μM U0126 (A). After the Isc stabilized, 10 μM amiloride was administered to the apical compartment and the difference in Isc before and after amiloride measured. Amiloride Isc increased in cells exposed to 0.4 dynes/cm² of FSS (#, p < 0.05) compared to static cells and this response was suppressed by U0126 (#, p < 0.05) compared to FSS alone.