TABLE 1.
Patients’ characteristics.
| LVEF ≤35% |
LVEF >35% |
|||||
| Survivor | Non-survivor | P* | Survivor | Non-survivor | P* | |
| Number of patients, n | 124 (84%) | 23 (16%) | 518 (96%) | 22 (4%) | ||
| Outcome | ||||||
| Follow-up (days), median (IQR) | 778 (590–1,024) | 499 (175–657) | <0.0001 | 769 (574–974) | 373 (203–696) | <0.0001 |
| Cardiac death | 0 (0%) | 18 (78%) | 0 (0%) | 14 (64%) | ||
| Demographic and clinical | ||||||
| Age (years), median (IQR) | 62 (53–71) | 63 (53–75) | 0.3 | 58 (49–67) | 69 (59–71) | 0.001 |
| Women | 37 (30%) | 10 (43%) | 0.1 | 215 (42%) | 10 (45%) | 0.7 |
| Body mass index (kg/m2), median (IQR) | 27.6 (24.5–31.2) | 28.3 (24.0–35.0) | 0.6 | 28.5 (25.4–32.1) | 28.4 (26.2–32.4) | 0.6 |
| Hypertension | 21 (17%) | 4 (17%) | 0.9 | 107 (21%) | 8 (36%) | 0.05 |
| Diabetes mellitus | 32 (26%) | 15 (65%) | 0.0002 | 128 (25%) | 17 (77%) | <0.0001 |
| Current smoker | 38 (31%) | 4 (17%) | 0.2 | 189 (36%) | 3 (14%) | 0.03 |
| BDI score ≥10 | 52 (42%) | 18 (78%) | 0.001 | 243 (47%) | 14 (64%) | 0.1 |
| History of myocardial infarction | 39 (31%) | 11 (48%) | 0.1 | 90 (17%) | 7 (32%) | 0.1 |
| History of coronary bypass surgery | 22 (18%) | 7 (30%) | 0.1 | 42 (8%) | 7 (32%) | <0.0001 |
| LVEF (%), median (IQR) | 30 (26–35) | 25 (20–30) | 0.0007 | 52 (45–55) | 45 (40–52) | 0.01 |
| Creatinine (mg/dL), median (IQR) | 1.0 (0.8–1.2) | 1.3 (1.1–2.3) | <0.0001 | 1.0(0.8–1.1) | 1.2 (0.9–2.1) | 0.01 |
| Index AMI | ||||||
| Killip class III-IV | 15 (12%) | 5 (22%) | 0.2 | 15 (3%) | 3 (14%) | 0.003 |
| Anterior wall AMI | 68 (55%) | 9 (39%) | 0.2 | 141 (27%) | 4 (18%) | 0.4 |
| Inferior wall AMI | 42 (34%) | 5 (22%) | 0.3 | 258 (50%) | 5 (23%) | 0.01 |
| Treatment | ||||||
| β-Blockers | 101 (81%) | 17 (74%) | 0.3 | 424 (82%) | 20 (91%) | 0.2 |
| Angiotensin converting enzyme inhibitors | 90 (73%) | 16 (70%) | 0.7 | 222 (43%) | 11 (50%) | 0.5 |
| Aspirin | 110 (89%) | 17 (74%) | 0.05 | 476 (92%) | 17 (77%) | 0.01 |
| Calcium channel blockers | 12 (10%) | 3 (13%) | 0.6 | 74 (14%) | 7 (32%) | 0.02 |
| Thrombolytic therapy after AMI | 38 (31%) | 6 (26%) | 0.7 | 173 (33%) | 2 (9%) | 0.02 |
| Coronary bypass after AMI | 27 (22%) | 1 (4%) | 0.05 | 73 (14%) | 2 (9%) | 0.5 |
| Coronary angioplasty<24 h after AMI | 66 (53%) | 4 (17%) | 0.004 | 334 (64%) | 12 (55%) | 0.2 |
| Acute reperfusion < = 12 h after AMI | 55 (44%) | 6 (26%) | 0.1 | 250 (48%) | 5 (23%) | 0.02 |
*Significance of difference by Wilcoxon two sample test for continuous variables and by chi-square test for categorical variables. AMI, acute myocardial infarction; LVEF, left ventricular ejection fraction.